Validation of a compact 1064nm time-domain DCS system

We developed a compact time-domain diffuse correlation spectroscopy (TD-DCS) system operating at 1064nm, aimed at bedside monitoring of cerebral blood flow for neonatal intensive care units. Designed to fit a mobile medical cart, the system was validated through solid phantom and human forearm cuff occlusion tests. The phantom test showed a depth sensitivity of at least 0.7 cm below the surface. The human test demonstrated reliable blood flow detection, consistent with time-domain near-infrared spectroscopy (TD-NIRS) and laser Doppler flowmetry. These findings support the feasibility of the compact TD‑DCS for intensive care unit and motivate future time‑gated approach and integration with TD‑NIRS to enable comprehensive hemodynamics and metabolism assessment.