A novel parametric fluid-structure interaction simulation to study corneal biomechanics

We present a novel, fully parametric 3D fluid–structure interaction (FSI) model developed in COMSOL Multiphysics® to simulate the biomechanical response of the eye to air puff deformation imaging. The framework allows systematic variation of air-puff dynamics, tissue properties, and anatomical geometries. The model replicates the pressurization phase and captures deformation metrics during the air puff, including deflection amplitude and peak distance among others. The model allows multi-plane analysis of corneal deformation, which improves the assessment of regional biomechanical behavior, critical for detecting diseases such as keratoconus. Overall, it offers new opportunities to enhance diagnostic precision and advance ophthalmic technologies.