High-speed ChRmine (hsChRmine) for cardiac optogenetic stimulation in mice

Diagnostic and Therapeutic Applications of Light in Cardiology 2026

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Authors: Abigail Matt, Fei Wang, Elena Gracheva, Hongwu Liang, Rosana Alfaro, Andrew Tang, Chao Zhou
DOI: 10.1117/12.3081603
Cited by: 0

Abstract

Cardiac arrythmias are a major cause of mortality and morbidity worldwide. Efficient research models are needed to develop therapies, but traditional methods of inducing arrythmia in mouse models have low success rates. Cardiac optogenetics provides a toolkit to create arrhythmia noninvasively, where light is used to control heart rhythm. Here, we developed a new mouse model expressing the high speed, red-shifted opsin hsChRmine evenly throughout heart tissue. Using large area illumination and low power density (

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias Photoreceptor and optogenetics research Cardiac Arrhythmias and Treatments

Publication details

Journal / source
Diagnostic and Therapeutic Applications of Light in Cardiology
Pages
16–16
Publication date
4 March 2026
Language
EN