Saliva-based diagnostics approach for oral cancer screening

Optical Diagnostics and Sensing: Toward Point-of-Care Diagnostics 2026

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Authors: Somali Dhal, Maria Victoria Fernandez, Sanathana Konugolu Venkata Sekar, Georges Humbert, Katarzyna Komolibus, Stefan Andersson‐Engels, Kellie A. Dean, Rekha Gautam
DOI: 10.1117/12.3082182
Cited by: 0

Abstract

Oral cancer remains a major health concern due to late diagnosis and limited non-invasive screening options. Saliva-based diagnostics offer a promising solution for early detection. This study presents a dual strategy to improve Raman spectroscopy analysis of saliva: refining filtration-based pre-analytical processing and developing a photonic crystal fiber (PCF)-based platform for waveguide-enhanced Raman signal collection, enabling non-invasive molecular diagnostics in liquid saliva.

Fields of Study & Subjects

Spectroscopy Techniques in Biomedical and Chemical Research Gold and Silver Nanoparticles Synthesis and Applications SARS-CoV-2 detection and testing

Publication details

Journal / source
Optical Diagnostics and Sensing: Toward Point-of-Care Diagnostics
Pages
11–11
Publication date
4 March 2026
Language
EN