Label-free optical coherence tomography and fluorescence lifetime imaging in translational cardiology

Recent advances in label-free optical imaging are transforming cardiovascular diagnostics by combining structural and biochemical insights. Intravascular optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) provide complementary information for assessing atherosclerotic disease. This talk will highlight combined intravascular OCT/FLIm for clinical studies, deep learning–based reconstruction of saturation-distorted lifetime signals, chromatic OCT for extended depth of focus, and super-resolution methods for enhancing OCT resolution. By integrating advanced optical designs with computational approaches, multimodal intravascular imaging offers next-generation diagnostic capabilities for translational cardiology.