Intravital imaging of the tumor microenvironment (TME) in oral cancers

Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2026

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Authors: Aditi Sahu, Samuel Auger, Hadar Gez-Reder, Emma Ann Finnegan, Ronald Ghossein, Snehal G. Patel, Milind M. Rajadhyaksha
DOI: 10.1117/12.3093355
Cited by: 0

Abstract

There is need to characterize the tumor microenvironment (TME) to improve survival and outcomes in oral squamous cell carcinoma (OSCC). Optical intravital imaging offers a unique opportunity to study spatial characterization of TME in situ directly in OSCC patients. Following our studies in skin cancers, we explore relative distribution of TME features such as inflammation, stroma and vasculature using reflectance confocal microscopy. We present our preliminary findings on retrospective imaging data acquired on patients diagnosed with OSCC and correlate with clinicopathological features.

Fields of Study & Subjects

Head and Neck Cancer Studies Optical Imaging and Spectroscopy Techniques Oral Health Pathology and Treatment

Publication details

Journal / source
Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology
Pages
12–12
Publication date
4 March 2026
Language
EN