Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation.

PubMed 2026 Open access

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Authors: Zhao Wang, Wei Dong, Xiangling Feng, Xinran Xu, Yao An, Huiling Xiao, Menghan Luo, Qian Liang, Ruoxuan Bai, Ke Zhao, Liuxing Wu, Lin Zhao
+13 more Yao Zhou, Xu Yi, Dandan Huang, Kaustav Sengupta, Dariusz M. Plewczynski, Pak Chung Sham, Chao Liu, Yang Yu, Wei Li, Qing Gong, Weihong Song, Wenhao Zhou, Mulin Jun Li
DOI: 10.1126/sciadv.ady2539
Cited by: 1

Abstract

expression and aberrant T cell hyperactivation. Our integrative and context-dependent strategy establishes a comprehensive pathway for deciphering the missing regulatory mechanisms of complex disease.

Fields of Study & Subjects

T-cell and B-cell Immunology Single-cell and spatial transcriptomics Genetic Associations and Epidemiology

Publication details

Journal / source
PubMed
Volume
12
Issue
1
Pages
eady2539–eady2539
Publication date
2 January 2026
Language
EN