From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles

Science Advances 2026 Open access

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Authors: Haoming Bao, Emily Xi Tan, Jie Zhou, Xiang Zhao, Sheng Yuan Leong, Chang Hoong Chek, Guo Kang Leon, Jaslyn Ru Ting Chen, Lam Bang Thanh Nguyen, Ling Li, Han Wei Hou, Hailong Zhang
+2 more In Yee Phang, Xing Yi Ling
DOI: 10.1126/sciadv.aec1846
Cited by: 1
References: 52

Abstract

, a regime inaccessible to conventional surface-enhanced Raman scattering (SERS) platforms. In silico simulations and experiments reveal ~20-fold enhancements in signal intensity and spatial reach compared to conventional nanoarrays. As a proof of concept, we demonstrate ultrasensitive, label-free classification of extracellular vesicles, 80 to 200 nm in diameter, derived from patients with colorectal cancer with 99.8% accuracy, surpassing traditional SERS (

Fields of Study & Subjects

Near-Field Optical Microscopy Gold and Silver Nanoparticles Synthesis and Applications Plasmonic and Surface Plasmon Research

Publication details

Journal / source
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Volume
12
Issue
20
Pages
eaec1846–eaec1846
Publication date
13 May 2026
Language
EN