Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States

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Authors: Mathew V. Kiang, Zehang Richard Li, Elizabeth Wrigley-Field, Rafeya V. Raquib, Dielle J. Lundberg, Eugenio Paglino, Benjamin Q. Huynh, Kirsten Bibbins-Domingo, M. Maria Glymour, Andrew Stokes
Cited by: 2
References: 88

Abstract

The actual number of US deaths caused by severe acute respiratory syndrome coronavirus 2 infection has been investigated and debated since the start of the COVID-19 pandemic. Here, we use machine learning trained on US death certificates from March 2020 to December 2021 to predict 155,536 (95% uncertainty interval: 150,062 to 161,112) unrecognized COVID-19 deaths. This indicates that 19% more COVID-19 deaths occurred in the US than officially reported. Predicted unrecognized COVID-19 deaths occurred disproportionately among decedents with less than a high school education; decedents identified as Hispanic, American Indian, Alaska Native, Asian, and/or Black; counties with lower household incomes and worse preexisting health; and counties in the South. These findings suggest that the US death investigation system undercounted COVID-19 deaths unevenly, hiding the true extent of inequities.

Fields of Study & Subjects

COVID-19 epidemiological studies Insurance Mortality Demography Risk Management COVID-19 and healthcare impacts

Publication details

Journal / source
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Volume
12
Issue
12
Pages
eaef5697–eaef5697
Publication date
18 March 2026
Language
EN