The tissue-specific regulation of immunobiology by IL-17 signaling
Abstract
IL-17 family cytokines are central regulators of tissue immunity. Here, we review recent advances in defining the cell- and tissue-specific activities of IL-17, emphasizing the signaling pathways engaged by IL-17 receptor (IL-17R) complexes and their associated downstream pathways. We highlight the intersecting transcriptional and posttranscriptional mechanisms that determine IL-17-driven responses and that underlie functional diversity across tissues. Last, we discuss emerging roles for IL-17 signaling in immunometabolism, neuroimmune interactions, cancer, and the latest approaches for targeted therapies.
Fields of Study & Subjects
Psoriasis: Treatment and Pathogenesis
Dermatology and Skin Diseases
Hidradenitis Suppurativa and Treatments
Publication details
- Journal / source
- Science Immunology
- Publisher
- American Association for the Advancement of Science (AAAS)
- Volume
- 11
- Issue
- 120
- Pages
- eadq6406–eadq6406
- Publication date
- 12 June 2026
- Language
- EN