Macrophages restrict tumor immune infiltration by controlling collagen topography.

PubMed 2026 Open access

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Authors: Zoé Fusilier, Alexandra Clément, Franck Simon, Isabel Calvente, Roude Jean-Marie, Mathilde Mathieu, Vincent Calmettes, Florence Piastra-Facon, Yazmina Quintana-Perez, Jeyani George Clément, Lou Crestey, Enola Lumineau
+18 more Romane Henninger, Mattia Tonani, Valeria Sandoval Manríquez, Lívia Lacerda Mariano, Léa Bensaid, Perrine de Villemagne, Eliane Piaggio, Vincent Semetey, Sylvie Coscoy, Emanuele Martini, Giorgio Scita, Jean‐Christophe Gelly, Johanna Ivaska, Hervé Isambert, Christel Goudot, Paolo Pierobon, Ana-Maria Lennon-Duménil, Hélène D. Moreau
DOI: 10.1126/sciimmunol.adw8291
Cited by: 3

Abstract

, and T cell and neutrophil signatures. Together, our data identify collagen network topographies as a key regulator of tumor-infiltrating immune cells.

Fields of Study & Subjects

Immune cells in cancer Cell Adhesion Molecules Research Single-cell and spatial transcriptomics

Publication details

Journal / source
PubMed
Volume
11
Issue
117
Pages
eadw8291–eadw8291
Publication date
20 March 2026
Language
EN