Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells

Science Immunology 2026

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Authors: Cait A. McAlindon, Rachael A. Clark

DOI: 10.1126/sciimmunol.aef9196

Cited by: 0

References: 1

Abstract

Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and drive T cell exhaustion.

Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology Immune cells in cancer

References 1