When HIV pays the price: Fitness costs behind lenacapavir resistance

Science Translational Medicine 2026

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Authors: Manish C. Choudhary, Jonathan Z. Li
DOI: 10.1126/scitranslmed.aed6475
Cited by: 2
References: 8

Abstract

HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer et al. , this issue).

Fields of Study & Subjects

HIV/AIDS drug development and treatment HIV Research and Treatment Evolution and Genetic Dynamics

Publication details

Journal / source
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Volume
18
Issue
831
Pages
eaed6475–eaed6475
Publication date
7 January 2026
Language
EN