Variable chlorhexidine MICs across Klebsiella species from a single facility

Antimicrobial Agents and Chemotherapy 2026 Open access

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Authors: David Lehman, Aubrey E Hetzler, Tayloe Friedrich, Madeline M Strouse, Katie E. Barry, Shireen Meher Kotay, Amy J. Mathers
DOI: 10.1128/aac.01436-25
Cited by: 0
References: 26

Abstract

ABSTRACT We assessed in vitro chlorhexidine minimal inhibitory concentrations (MICs) across Klebsiella species from a hospital with widespread chlorhexidine use. Isolates underwent MIC testing and whole genome sequencing. Species showed varying resistance, with Klebsiella quasipneumoniae having the highest MICs. There was no clear link to acquired resistance, but some species had more chromosomal efflux pumps. Differences in chlorhexidine MICs between species highlight the role that biocides could have in shaping microbial populations in the hospital environment.

Fields of Study & Subjects

Antimicrobial agents and applications Antibiotic Resistance in Bacteria Infection Control in Healthcare

Publication details

Journal / source
Antimicrobial Agents and Chemotherapy
Volume
70
Issue
3
Pages
e0143625–e0143625
Publication date
9 February 2026
Language
EN