The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused by Coccidioides immitis

Antimicrobial Agents and Chemotherapy 2026 Open access

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Authors: Nathan P. Wiederhold, Laura K. Najvar, Rosie Jaramillo, Marcos Olivo, T F Patterson
DOI: 10.1128/aac.01469-25
Cited by: 1
References: 14

Abstract

ABSTRACT We evaluated the in vivo activity of EL219 against central nervous system coccidioidomycosis. Mice were inoculated intracranially with arthroconidia of Coccidioides immitis , and treatment with EL219 (5, 10, or 20 mg/kg QD by intraperitoneal injection) or fluconazole (25 mg/kg orally BID) began 2 days later. Each dose of EL219 and fluconazole significantly improved survival. Brain fungal burden was also reduced compared to vehicle control. Further studies of EL219 against coccidioidomycosis are warranted.

Fields of Study & Subjects

Fungal Infections and Studies Antifungal resistance and susceptibility Nail Diseases and Treatments

Publication details

Journal / source
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Volume
70
Issue
3
Pages
e0146925–e0146925
Publication date
26 January 2026
Language
EN