First identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in Haemophilus influenzae in the Iberian Peninsula

Antimicrobial Agents and Chemotherapy 2026 Open access

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Authors: Aída González-Díaz, M. Bessa Pinto, Irene Cadenas-Jiménez, Sara Lia Duarte, Carmen Ardanuy, M. Manuela Ribeiro, Sara Martí, Maria Paula Bajanca-Lavado
DOI: 10.1128/aac.01649-25
Cited by: 0
References: 27

Abstract

ABSTRACT We describe, for the first time, the presence and characterization of CTX-M-15 and OXA-9 in two Haemophilus influenzae strains: PTHi-14525 (CTX-M-15) from Portugal and HUB-HI042681 (OXA-9) from Spain. Multidrug-resistant PTHi-14525 carried bla CTX-M-15 (two copies) and bla TEM-1 in an ICE HpaHUB5-like element. HUB-HI042681, resistant to β-lactams and aminoglycosides, carried a novel ICE HinHUB1 . These findings highlight the genomic plasticity and expanded resistome of H. influenzae , raising concerns about treatment and emphasizing the need for continuous genomic surveillance.

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Antimicrobial Resistance in Staphylococcus Infections and bacterial resistance

Publication details

Journal / source
Antimicrobial Agents and Chemotherapy
Volume
70
Issue
3
Pages
e0164925–e0164925
Publication date
30 January 2026
Language
EN