Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model

Antimicrobial Agents and Chemotherapy 2026 Open access

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Authors: Marin Lahouati, Vasco Dias Meireles, Camille Rougnon-Glasson, Antoine Petitcollin, Fabien Xuereb
DOI: 10.1128/aac.01660-25
Cited by: 0
References: 10

Abstract

ABSTRACT Cerebrospinal fluid (CSF) penetration of delafloxacin was evaluated in a murine model. Mice received a single 40 mg/kg intraperitoneal dose. Plasma and CSF samples were collected at five time points over 4 h and analyzed by ultra high-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Pharmacokinetic parameters, including CSF penetration ratio (AUC 0–4h CSF/AUC 0–4h plasma), were determined using a non-compartmental model. The CSF penetration ratio of delafloxacin was 49%. Cmax/MIC ratios met pharmacokinetic/pharmacodynamic targets for Staphylococcus and Streptococcus spp., but not Enterobacterales.

Fields of Study & Subjects

Antibiotics Pharmacokinetics and Efficacy Bacterial Infections and Vaccines Antimicrobial Resistance in Staphylococcus

Publication details

Journal / source
Antimicrobial Agents and Chemotherapy
Volume
70
Issue
2
Pages
e0166025–e0166025
Publication date
14 January 2026
Language
EN