Mapping the monoclonal antibody landscape of human cytomegalovirus
Abstract
Human cytomegalovirus (HCMV) is a major cause of congenital disease and a significant threat to immunocompromised individuals, particularly transplant recipients and neonates. Over the past five decades, numerous monoclonal antibodies (mAbs) targeting various HCMV antigens have been isolated. Here, we present a comprehensive review of HCMV-specific mAbs isolated from the 1980s to the present, detailing their target antigens, epitopes, neutralizing activity, and potential clinical applications. This review integrates historical discoveries with recent structural and functional studies, highlighting trends that may inform the development of anti-HCMV therapeutics and prophylactics.
Fields of Study & Subjects
Cytomegalovirus and herpesvirus research
Systemic Lupus Erythematosus Research
Parvovirus B19 Infection Studies
Publication details
- Journal / source
- Journal of Virology
- Publisher
- American Society for Microbiology
- Volume
- 100
- Issue
- 7
- Pages
- e0032526–e0032526
- Publication date
- 15 June 2026
- Language
- EN