Pre-assembled complexes and allosteric effects: parallels between eukaryotic phosphorylation cascades and membrane fusion during herpesviral entry
Abstract
distribute cell entry functions across several viral envelope proteins. The prevailing model posits that, upon interaction with the target cell, the activating signal is transmitted from the receptor-binding to the fusion-mediating component in a signaling cascade that involves sequential interactions. However, herpesvirus entry proteins may form complexes throughout fusion. Here, we propose that-by analogy with certain eukaryotic signaling cascades-transmission of the activating signal involves pre-assembled complexes and allosteric effects.
Fields of Study & Subjects
Herpesvirus Infections and Treatments
Viral-associated cancers and disorders
Cytomegalovirus and herpesvirus research
Publication details
- Journal / source
- Journal of Virology
- Publisher
- American Society for Microbiology
- Volume
- 100
- Issue
- 2
- Pages
- e0170424–e0170424
- Publication date
- 5 January 2026
- Language
- EN