High-depth RNA-seq data to investigate gene regulation mediated by phase-variable DNA methyltransferases in serogroup B Neisseria meningitidis

Microbiology Resource Announcements 2026 Open access

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Authors: Alice Ascari, Luke V. Blakeway, Michael P Jennings, Kate L. Seib
DOI: 10.1128/mra.00163-26
Cited by: 1
References: 9

Abstract

ABSTRACT Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia. Here, we report high-depth RNA-seq for N. meningitidis serogroup B strains MC58, B6116/77, and M0579. These strains encode phase-variable DNA methyltransferases ModA11, ModA12, and ModD1, respectively, which act as global epigenetic regulators central to meningococcal pathogenicity.

Fields of Study & Subjects

Bacterial Infections and Vaccines Bacterial Genetics and Biotechnology Metalloenzymes and iron-sulfur proteins

Publication details

Journal / source
Microbiology Resource Announcements
Publisher
American Society for Microbiology
Volume
15
Issue
6
Pages
e0016326–e0016326
Publication date
29 April 2026
Language
EN