Synthesis, Structures and Urease Inhibition Studies of Cobalt(II) and Copper(I) Complexes with Thiosemicarbazone Ligands

Journal of Structural Chemistry 2026

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Authors: Y. Frank Chen, B. Qiu, Y. -J. Xu, W. -B. Yan, S. -J. Liu, X. -Y. Qiu
DOI: 10.1134/s0022476626010075
Cited by: 1
References: 30

Abstract

Abstract New cobalt(II) and copper(I) complexes, [CoCl2(L1)2] (1) and [CuClL2(Ph3P)2]·CH3CN (2), where L1 = 1-(4-bromobenzylidene)thiosemicarbazide, L2 = 1-(2,4-dichlorobenzylidene)thiosemicarbazide, PPh3 = = triphenylphosphine, were synthesized and characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The complexes were also tested for their urease inhibitory properties. The cobalt complex has strong activity (IC50 = 5.7 μM). Enzymatic kinetics research suggested that the cobalt complex is a non-competitive urease inhibitor.

Fields of Study & Subjects

Microbial Applications in Construction Materials Metal complexes synthesis and properties Metal-Catalyzed Oxygenation Mechanisms

Publication details

Journal / source
Journal of Structural Chemistry
Publisher
Pleiades Publishing Ltd
Volume
67
Issue
1
Pages
65–74
Publication date
1 January 2026
Language
EN