A New Approach to the Synthesis of Sydnonimines Carboxyethylated at the Exocyclic Nitrogen Atom

Abstract Objective: A new library of sydnonimines containing a carboxyethyl group at the exocyclic nitrogen atom was presented. Methods: Four-step synthesis including cyanomethylation, N-nitrosation, cyclization, and final introduction of a carboxyethyl group was used to obtain new sydnonimines. Results and Discussion: We discovered that the proposed approach can be optimized for a gram-scale synthesis with a single chromatographic step. Our method can be applied to obtain libraries of potential biologically active compounds of this class. Conclusions: We designed a new series of sydnonimines with a carboxyethyl group at the exocyclic nitrogen atom. Going forward, the synthesized substances can be potentially used in new promising drug design.