Synthesis of a Novel Spiro-Oxadiazolidines by the Reaction of 1,3-Dipolar Cycloaddition of Nitrile Oxides to 2-Iminothiazolidines
Abstract
Abstract Nitrile oxides are known in various reactions of 1,3-dipolar cycloaddition, where examples of the interaction of this dipole along exocyclic multiple carbon–carbon and carbon–heteroatom bonds are of particular interest. Such substrates can be used to create spiro-conjugated heterocyclic systems with high conformational rigidity, allowing achieving the required stereoelectronic properties in the resulting molecules. Herein, we propose a novel approach to the synthesis of spiro-oxadiazolidines by the reaction of nitrile oxides with 2-iminothiazolidines, which proceeds without isomerization of the starting heterocycles.
Fields of Study & Subjects
Structural and Chemical Analysis of Organic and Inorganic Compounds
Organic Chemistry Cycloaddition Reactions
Chemical synthesis and pharmacological studies
Publication details
- Journal / source
- Russian Journal of General Chemistry
- Volume
- 96
- Issue
- 2
- Publication date
- 1 February 2026
- Language
- EN