Synthesis and Properties of 3-Amino-4-(4-methoxyphenyl)-6-oxo-4,5,6,7-tetrahydrothieno[2,3-b]pyridines

Russian Journal of General Chemistry 2026 Open access

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Authors: Ruslan V. Kyarov, Philipp A. Popov, Arina G. Levchenko, Polina G. Dahno, Т.Л. Цымбал, Eva S. Daus, Tatyana R. Hagur, Alisa A. Khomyakova, Anastasiia E. Abramova, Nicolai A. Katyshkov, Nicolai A. Aksenov, Inna V. Aksenova
+2 more Victor V. Dotsenko, Sergey Gennadievich Krivokolysko
DOI: 10.1134/s1070363226600116
Cited by: 1
References: 93

Abstract

Abstract A series of previously undescribed 3-amino-4,5,6,7-tetrahydrothieno[2,3- b ]pyridines was prepared in 44–79% yields through alkylation of N -methylmorpholinium 3-cyano-4-(4-methoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolate followed by Thorpe–Ziegler cyclization in the presence of KOH. An in silico predictor analysis was conducted to determine the bioavailability parameters and potential protein targets for the new compounds. Under laboratory experimental conditions on sunflower seedlings, some of the synthesized compounds demonstrated a moderate antidote effect against the herbicide 2,4-D.

Fields of Study & Subjects

Synthesis and Reactivity of Sulfur-Containing Compounds Synthesis and Reactivity of Heterocycles Organic Chemistry Synthesis Methods

Publication details

Journal / source
Russian Journal of General Chemistry
Publisher
Pleiades Publishing Ltd
Volume
96
Issue
8
Publication date
9 July 2026
Language
EN