Preparation of Core-Shell Nanofibers and Insights from Molecular Dynamics Simulations for Interaction between Polycaprolactone Core and Collagen Shell
Abstract
Abstract For the first time, coaxial nanofibrous matrices with a core-shell polycaprolactone-collagen (PCL-Col) structure were obtained without the use of plasticizers and thickeners, in which PCL should provide mechanical strength, and Col should provide improved biocompatibility. The obtained matrix does not require additional processing to remove solvents. For the first time, the interaction of the PCL and Col was modeled and quantitatively estimated using the molecular dynamics method. The simulation revealed a stable nature of the physical binding of PCL with Col, which is preserved even at room temperature. It was found that the interaction between the components is due to physical interaction (hydrogen bonds, electrostatic interaction) without the formation of covalent bonds, which ensures the preservation of the native structure and bioactive properties of Col.
Fields of Study & Subjects
Collagen: Extraction and Characterization
Electrospun Nanofibers in Biomedical Applications
Hydrogels: synthesis
properties
applications
Publication details
- Journal / source
- Inorganic Materials Applied Research
- Publisher
- Pleiades Publishing Ltd
- Volume
- 17
- Issue
- 2
- Pages
- 345–350
- Publication date
- 1 April 2026
- Language
- EN