Automated oxygen flow titration for infants with bronchiolitis: a multicentre randomised controlled trial

Archives of Disease in Childhood 2026 Open access

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Authors: Pierrick Cros, Adélie Martin, Maëlys Consigny, Tiphaine Bihouée, Alexandra Masson, Lea Gaitan, Jean‐Michel Roué
DOI: 10.1136/archdischild-2025-329523
Cited by: 1
References: 30

Abstract

OBJECTIVE: To compare automated closed-loop oxygen therapy using the FreeO2 device versus conventional manual oxygen therapy with regard to length of hospital stay among spontaneously breathing infants with bronchiolitis. DESIGN: Multicentre randomised controlled trial conducted from 2018 to 2023. SETTING: Ten paediatric departments across France. PATIENTS: 98%). RESULTS: The median hospital stay was 71.00 hours (IQR 45.8-97.6) in the FreeO2 group and 69.6 hours (IQR 47.5-116.7) in the manual group (p=0.39). The percentage of time within the oxygen target zone was 89.4% in the FreeO2 group vs 74.9% in the manual group (p

Fields of Study & Subjects

Respiratory viral infections research Neonatal Respiratory Health Research Respiratory Support and Mechanisms

Publication details

Journal / source
Archives of Disease in Childhood
Publisher
BMJ
Volume
111
Issue
11
Pages
archdischild–2025
Publication date
14 May 2026
Language
EN