Radiotherapy for extramedullary haematopoiesis of the mandibular mucosa secondary to myelofibrosis

BMJ Case Reports 2026

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Authors: Justin Smith, Claire Weatherburn, Serena Kosciejew, Caroline Louise Cooper, Yoo Young Lee
DOI: 10.1136/bcr-2025-267107
Cited by: 0
References: 8

Abstract

Extramedullary haematopoiesis (EMH) is a clinical manifestation of myelofibrosis (MF), which can lead to significant localised symptoms. A patient in her 70s with a history of MF presented with a symptomatic bleeding site of EMH in the right mandibular mucosa following dental removal, which limited her oral intake to a liquid diet. The EMH site was treated with radiotherapy (RT), administering 10 Gy in five fractions and another 10 Gy in five fractions 3 months later, resulting in a complete response and resolution of symptoms. This case highlights that RT is an effective and well-tolerated treatment for patients with symptomatic sites of EMH.

Fields of Study & Subjects

Myeloproliferative Neoplasms: Diagnosis and Treatment Oral health in cancer treatment Acute Myeloid Leukemia Research

Publication details

Journal / source
BMJ Case Reports
Volume
19
Issue
2
Pages
e267107–e267107
Publication date
1 February 2026
Language
EN