Gastric synovial sarcoma: the critical role of molecular techniques in diagnosis of an ultra-rare cancer
Abstract
Gastric synovial sarcoma (GSS) is an exceptionally rare mesenchymal malignancy, with only 51 cases reported. We present a case of a man in his 50s with dyspeptic symptoms and epigastric pain. Gastroscopy revealed an ulcerous tumour below the gastro-oesophageal junction. Histology, immunohistochemistry and molecular analysis confirmed SS18::SSX1 fusion, diagnostic of synovial sarcoma. The patient underwent successful robot-assisted partial gastric resection with negative margins. No recurrence was noted at 6-month follow-up. This case underscores the diagnostic challenge of GSS, the critical role of molecular techniques and the efficacy of minimally invasive surgical management.
Fields of Study & Subjects
Sarcoma Diagnosis and Treatment
Gastrointestinal Tumor Research and Treatment
Metastasis and carcinoma case studies
Publication details
- Journal / source
- BMJ Case Reports
- Publisher
- BMJ
- Volume
- 19
- Issue
- 4
- Pages
- e267170–e267170
- Publication date
- 1 April 2026
- Language
- EN