Peripheral T-cell lymphoma-NOS presenting with cavitary lung lesions mimicking invasive aspergillosis
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is a rare subtype of non-Hodgkin lymphoma that frequently presents with multiorgan involvement. We report a diagnostically challenging case of a female in her late 40s presenting with otomastoiditis, brain abscess and bilateral cavitary lung lesions. A positive serum galactomannan led to empiric antifungal therapy for presumed disseminated aspergillosis. However, tissue biopsies were negative for infection, and histopathology ultimately confirmed PTCL-NOS. This case highlights a rare presentation of PTCL-NOS, involving both the lungs and central nervous system, mimicking invasive fungal disease.
Fields of Study & Subjects
Lymphoma Diagnosis and Treatment
CNS Lymphoma Diagnosis and Treatment
Viral-associated cancers and disorders
Publication details
- Journal / source
- BMJ Case Reports
- Volume
- 19
- Issue
- 3
- Pages
- e268805–e268805
- Publication date
- 1 March 2026
- Language
- EN