Febrile neutropenia in a patient with non-small cell lung cancer treated with nivolumab

BMJ Case Reports 2026

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Authors: Elise Newman, Farah Tahir, Swe Myo Htet, Wasek Faisal
DOI: 10.1136/bcr-2025-270744
Cited by: 1
References: 19

Abstract

We describe a case of febrile neutropenia in a patient with metastatic non-small cell lung cancer, occurring after 36 cycles of nivolumab therapy. A bone marrow aspirate was performed which showed myeloid maturation arrest without a clear alternative cause, supporting an immune-mediated mechanism. The patient responded well to broad-spectrum antibiotics and granulocyte colony-stimulating factor (G-CSF), with successful rechallenge until other immune-related toxicities led to discontinuation. While uncommon, haematological immune-related adverse events are potentially life-threatening, with neutropenia reported in

Fields of Study & Subjects

Blood disorders and treatments Neutropenia and Cancer Infections Hematological disorders and diagnostics

Publication details

Journal / source
BMJ Case Reports
Publisher
BMJ
Volume
19
Issue
4
Pages
e270744–e270744
Publication date
1 April 2026
Language
EN