Subretinal drusenoid deposits (reticular pseudodrusen) in the general population: a European multicohort study

British Journal of Ophthalmology 2026

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Authors: Matthias Marten Mauschitz, Frank G Holz, Alexander K Schuster, Stephanie D. Grabitz, Jost B. Jonas, Mukharram Mukhtaramovich Bikbov, Gyulli M. Kazakbaeva, Ruth Hogg, Tunde Peto, Catherine P Creuzot-Garcher, Pierre-Henry Gabrielle, Rita Coimbra
+6 more Cláudia Farinha, Cecile Delcourt, Audrey Cougnard‐Grégoire, Caroline Brandl, Iris M. Heid, Robert Patrick Finger
DOI: 10.1136/bjo-2025-329334
Cited by: 1
References: 52

Abstract

BACKGROUND/AIMS: To investigate the prevalence and determinants of subretinal drusenoid deposits (SDDs; also known as reticular pseudodrusen, RPDs) in the European general population. METHODS: Altogether 18 931 adults from eight population-based studies were included. SDDs/RPDs were determined on optical coherence tomography and/or infrared photography. The prevalence of SDDs/RPDs and associated ocular and systemic determinants using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis were analysed. RESULTS: Mean age ranged from 58.7±10.6 to 88.4±0.0 years in the different studies and prevalence of SDDs/RPDs ranged from 0.6% to 56.0%. Meta-analyses showed that increasing age (OR 1.09 per year, 95% CI 1.04 to 1.13; p

Fields of Study & Subjects

Retinal Diseases and Treatments Ocular Diseases and Behçet’s Syndrome Cerebral Venous Sinus Thrombosis

Publication details

Journal / source
British Journal of Ophthalmology
Publisher
BMJ
Pages
bjo–2025
Publication date
8 June 2026
Language
EN