Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes

BMJ Open Diabetes Research & Care 2026 Open access

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Authors: Zachary Chaffin, Simona Ghetti, Daniel Joseph Tancredi, Arleta Rewers, Marian Rewers, Spencer Gilles, Bradley P. Ander, Nicole S. Glaser
DOI: 10.1136/bmjdrc-2025-004961
Cited by: 0
References: 32

Abstract

INTRODUCTION: Diabetic ketoacidosis (DKA) occurs frequently in children with type 1 diabetes (T1D). The inflammatory response to DKA may play a role in complications, but the inflammatory pattern is not well characterized. We aimed to describe the inflammatory profile during and after DKA. RESEARCH DESIGN AND METHODS: We evaluated inflammatory mediators (cytokines, chemokines, growth factors, and matrix metalloproteinases) using multiplex immunoassays in children (1) hospitalized with acute DKA (6-8 hours after beginning treatment, (n=15), (2) seen in the outpatient diabetes clinic 2-5 days after DKA (n=14), (3) hospitalized with new-onset T1D without DKA

Fields of Study & Subjects

Diabetes Management and Research Diabetes and associated disorders Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
BMJ Open Diabetes Research & Care
Volume
14
Issue
2
Pages
e004961–e004961
Publication date
1 January 2026
Language
EN