Serum soluble ASGR1 concentration is elevated in patients with metabolic dysfunction-associated steatotic liver disease and is associated with adiponectin
Abstract
INTRODUCTION: Current studies have shown that the asialoglycoprotein receptor 1 (ASGR1) is involved in glycolipid metabolism and is associated with systemic insulin resistance. This study aims to explore the correlation between serum soluble ASGR1 (sASGR1) levels and metabolic dysfunction-associated steatotic liver disease (MASLD) by assessing the relationship between sASGR1 concentrations and various biomarker levels. METHODS: The study included 148 patients diagnosed with MASLD from December 2021 to July 2024, and 98 control participants from the general population without MASLD. After collecting baseline clinical characteristics, ELISA kits were used to measure serum levels of sASGR1, fibroblast growth factor 21, and adiponectin. RESULTS: Compared with the control group, patients with MASLD had higher serum sASGR1 levels (p
Fields of Study & Subjects
Liver Disease Diagnosis and Treatment
Liver Diseases and Immunity
Growth Hormone and Insulin-like Growth Factors
Publication details
- Journal / source
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Volume
- 14
- Issue
- 1
- Pages
- e005638–e005638
- Publication date
- 1 January 2026
- Language
- EN