Association of extraintestinal manifestations and disease severity in paediatric inflammatory bowel disease: a multicentre cohort study

BMJ Open Gastroenterology 2026 Open access

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Authors: Ágnes Eszter Tímár, Márk Hernádfői, Brigitta Teutsch, Zsolt Abonyi-Tóth, Nelli Farkas, Zoltán Sipos, Péter Hegyi, Anna Karoliny, A. Párniczky, Áron Cseh, Antal Dezsőfi, Miklós Garami
+11 more Judit Czelecz, Ildikó Guthy, Márta Kovács, Ágnes Horváth, Márta Balogh, András Tárnok, Dániel Szűcs, Orsolya Kadenczki, Éva Kosaras, Natália Lásztity, Katalin Eszter Müller
DOI: 10.1136/bmjgast-2025-002130
Cited by: 0
References: 35

Abstract

OBJECTIVE: Extraintestinal manifestations (EIMs) are common in paediatric inflammatory bowel disease (IBD), often impairing quality of life. Our aim was to assess whether EIMs at diagnosis are associated with disease severity in paediatric IBD. METHODS: We conducted a post hoc analysis from the Hungarian Pediatric IBD Registry (2010-2020), including children with Crohn's disease (CD) or ulcerative colitis (UC). Outcomes (relapse, steroid dependency, biological therapy (BT), surgery) were compared between patients with EIMs at diagnosis and those without, using Kaplan-Meier and Cox regression analyses. RESULTS: Among 1590 patients, EIMs were more frequent in CD than in UC (25% vs 14%, p

Fields of Study & Subjects

Inflammatory Bowel Disease Ocular Diseases and Behçet’s Syndrome Autoimmune and Inflammatory Disorders

Publication details

Journal / source
BMJ Open Gastroenterology
Volume
13
Issue
1
Pages
e002130–e002130
Publication date
1 February 2026
Language
EN