CXCR4 mRNA overexpression: an indicator of poor survival and predictor of response to immune checkpoint inhibitors in patients with metastatic colorectal cancer

BMJ Oncology 2026 Open access

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Authors: Sepideh Gholami, Anwaar Saeed, Yasmine Baca, Andrew C. Hinton, Lyudmyla Demyan, Mustafa Faleh Abidalhassan, Joanne Xiu, Gulam Abbas Manji, Andreas Seeber, Benjamin A Weinberg, Moh’d Khushman, Anthony F Shields
+3 more Heinz-Josef Lenz, John Marshall, Emil Lou
DOI: 10.1136/bmjonc-2025-001003
Cited by: 1
References: 57

Abstract

Objective Expression of CXC-chemokine receptor 4 (CXCR4) is associated with poor prognosis in colorectal cancer (CRC), metastasis and immune cell infiltration. Currently, only patients with metastatic CRC with mismatch repair deficient (dMMR) tumours (

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Chemokine receptors and signaling Colorectal Cancer Treatments and Studies

Publication details

Journal / source
BMJ Oncology
Publisher
BMJ
Volume
5
Issue
1
Pages
e001003–e001003
Publication date
1 January 2026
Language
EN