Balloon plus oxytocin or oral misoprostol for labour induction in prelabour rupture of membranes (PROM): protocol for a randomised controlled trial (RUBAPRO2)

BMJ Open 2026 Open access

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Authors: Marion Rouzaire, Alexia Triolaire, Christophe Vayssière, Loı̈c Sentilhes, Thiphaine Barjat, Dominique Luton, Groupe de Recherche en Obstetrique et Gynécologie (GROG) Investigators, Estelle Davoust, Aurélie Cabrespine, Bruno Pereira, Denis Gallot
DOI: 10.1136/bmjopen-2025-110425
Cited by: 0
References: 26

Abstract

INTRODUCTION: The optimal strategy for induction of labour (IOL) in cases of prelabour rupture of membranes (PROM) with an unfavourable cervix is elusive. No study conducted in nulliparous women has shown any one induction method to be superior to any other. In this project, we seek to determine whether IOL with balloon catheter and oxytocin can (1) increase rate of delivery

Fields of Study & Subjects

Maternal and Perinatal Health Interventions Preterm Birth and Chorioamnionitis Reproductive Health and Contraception

Publication details

Journal / source
BMJ Open
Volume
16
Issue
1
Pages
e110425–e110425
Publication date
1 January 2026
Language
EN