Gut microbiome profile among children and adolescents living with sickle cell disease: a protocol for systematic review and meta-analysis

BMJ Open 2026 Open access

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Authors: AO Salako, Joseph Ogbeh, Hafeez Aderinsayo Adekola, O O Odubela, Folahanmi Tomiwa Akinsolu, Ruqqayah Jimoh, Tomilola Ebunoluwa Musari-Martins, Samson A. Luka, Abdulrasheed Oba, Daniel Ayegbeso, Oluwatosin Odubela, Titilola Abike Gbaja-Biamila
+2 more Adesola Zaidat Musa, Babatunde Lawal Salako
DOI: 10.1136/bmjopen-2025-111353
Cited by: 0
References: 22

Abstract

INTRODUCTION: This systematic review aims to synthesise current evidence on gut microbiome profiles among children with sickle cell disease (SCD), assess the influence of analgesic and antibiotic use, and explore the contributions of environmental factors on their gut microbiota diversity. Through identification of consistent microbial patterns and gaps in the existing literature, this review will provide vital insight into potential microbiome-targeted strategies for improving health outcomes in paediatric SCD care. METHODS AND ANALYSIS: Studies describing the gut microbiota among paediatric SCD human subjects (

Fields of Study & Subjects

Gut microbiota and health Hemoglobinopathies and Related Disorders Gastrointestinal motility and disorders

Publication details

Journal / source
BMJ Open
Volume
16
Issue
2
Pages
e111353–e111353
Publication date
1 February 2026
Language
EN