Lower versus standard dose-intensity continuous renal replacement therapy: a protocol for a systematic review and meta-analysis

BMJ Open 2026 Open access

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Authors: Nuttha Lumlertgul, Prit Kusirisin, Janice Y Kung, D’Arcy Duquette, Tomoko Fujii, Alexander Zarbock, Ron Wald, Sean M. Bagshaw
DOI: 10.1136/bmjopen-2025-112086
Cited by: 2
References: 19

Abstract

INTRODUCTION: The 2012 Kidney Diseases Improving Global Outcomes clinical practice guideline recommends prescribing continuous renal replacement therapy (CRRT) doses in patients with acute kidney injury (AKI) between 20 and 25 mL/kg/hour, with a need to consider further augmentation to 25-30 mL/kg/hour. Observational data have shown that lower-dose CRRT (

Fields of Study & Subjects

Acute Kidney Injury Research Dialysis and Renal Disease Management Chronic Kidney Disease and Diabetes

Publication details

Journal / source
BMJ Open
Publisher
BMJ
Volume
16
Issue
1
Pages
e112086–e112086
Publication date
1 January 2026
Language
EN