Systemic and local vascular features in branch retinal vein occlusion: analysis of the retinal age gap and crossing pattern

BACKGROUND/AIMS: To evaluate the respective roles of systemic vascular vulnerability and local vascular anatomy in the onset of branch retinal vein occlusion (BRVO) by analysing the retinal age gap and arteriovenous crossing patterns. METHODS: This observational study enrolled 202 patients with unilateral BRVO and 100 age-matched, sex-matched and axial length-matched healthy controls. A deep learning model was applied to colour fundus images to estimate the retinal age; the retinal age gap (predicted retinal age minus chronological age) in the fellow eye was used as a surrogate residual marker of systemic vascular vulnerability. At the occlusion site, arteriovenous crossing was classified (arterial vs venous overcrossing) using optical coherence tomography angiography (OCTA). RESULTS: The mean retinal age gap was 1.8±6.5 years and 0.2±6.0 years in the BRVO and control groups, respectively. Retinal age gap was significantly larger in BRVO eyes than in control eyes (p=0.046). A larger retinal age gap in the fellow eye correlated with younger age at BRVO onset (ρ= -0.350, p