125 Impact of the Different Treatment Regimens on Weight Changes in Children with Acute Lymphoblastic Leukaemia and Evaluation of Dietetic Service Provision: Single-Centre Retrospective Study

Nutritional status is an important determinant of treatment tolerance and long-term outcomes in children with acute lymphoblastic leukaemia (ALL). Both undernutrition and excessive weight gain are associated with complications, including sarcopenic obesity. 1–3 However, there are limited data on weight trajectories and dietetic provision services for this group at Great Ormond Street Hospital (GOSH). Our aim is to describe changes in weight during treatment and monitor dietetic input.Data were collected retrospectively using electronic medical records (EPIC). The inclusion criteria were children aged 1–11 years, diagnosed with ALL, and under the care of GOSH between June 2019 and June 2025. Demographics, treatment phase and regimens, serial weights, and dietetic contacts were collected. Data from 122 children were analysed; 55 (44%) were female, and 95% had B-cell ALL. The mean age at treatment initiation was 4.7 years (SD, 2.3) and 7.2 years at completion (p = 0.02). Weight-for-age and BMI z-scores increased from 0.2 to 0.5 (p=0.05); 0.15 to 0.76 (p