Estimated plasma volume for predicting sepsis-associated ARDS risk: a multicentre retrospective cohort study

BMJ Open Respiratory Research 2026 Open access

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Authors: Lina Zhao, Lei Zong, Wei Wei, Yuehao Shen, Haiying Liu, X Li, Dongxue Huang, Daihua Yu, Fei Yang, Yunying Wang, Xiaopeng Shi, Yun Li
+2 more Y L Wang, Keliang Xie
DOI: 10.1136/bmjresp-2025-003471
Cited by: 1
References: 28

Abstract

BACKGROUND: Sepsis-associated acute respiratory distress syndrome (SA-ARDS) is a lethal complication demanding early predictors. This study assessed estimated plasma volume status (ePVS) for predicting SA-ARDS development. METHODS: This multicentre cohort study analysed 3854 adult patients with sepsis 3.0 from China. The primary outcome was the incidence of SA-ARDS. Multivariate logistic regression, propensity score matching (PSM) and inverse probability weighting (IPW) were used to assess associations between ePVS and SA-ARDS. RESULTS: Elevated ePVS was independently associated with SA-ARDS incidence across all models (multivariate OR: 1.56, 95% CI 1.50 to 1.63; PSM OR: 1.72, 1.63 to 1.81; IPW OR: 1.58, 1.49 to 1.69; p

Fields of Study & Subjects

Sepsis Diagnosis and Treatment Respiratory Support and Mechanisms Hemodynamic Monitoring and Therapy

Publication details

Journal / source
BMJ Open Respiratory Research
Publisher
BMJ
Volume
13
Issue
1
Pages
e003471–e003471
Publication date
1 June 2026
Language
EN