Insights from the PHENIX trial: sentinel lymph node biopsy in surgical treatment for early-stage cervical cancer
Abstract
Cervical cancer is a malignant disease that poses a serious threat to women’s health. For early-stage cervical cancer, surgery remains the primary treatment, with pelvic lymph node dissection (PLND) serving as a crucial component. However, this procedure has inherent limitations. Since the majority of early-stage patients do not have lymph node metastases, routine PLND may lead to overtreatment and is associated with various complications such as lymphoedema, venous thrombosis and lymphocyst formation. Furthermore, PLND may disrupt the anatomical basis for immune surveillance. In the era of precision medicine, there is a growing imperative to re-evaluate this classic surgical approach.
Fields of Study & Subjects
Endometrial and Cervical Cancer Treatments
Cervical Cancer and HPV Research
Ovarian cancer diagnosis and treatment
Publication details
- Journal / source
- Gynecology and Obstetrics Clinical Medicine
- Volume
- 6
- Issue
- 1
- Pages
- e000439–e000439
- Publication date
- 1 March 2026
- Language
- EN