Clinical impact of Takotsubo syndrome in patients with stroke

BACKGROUND: Data on outcomes of patients complicating with Takotsubo syndrome (TTS) following stroke, contributing factors and prognosis significance have not been well characterised. OBJECTIVE: To assess the incidence, factors and prognosis of TTS-complicated stroke, and to determine the 30-day unplanned readmission rates with TTS and its prognosis among stroke survivors without initial TTS. METHODS: The US Nationwide Readmission Database was queried using International Classification of Disease codes to gather information on individuals hospitalised with primary diagnosis of stroke between January 2010 and November 2021. Incidence, factors and prognosis associated with TTS-complicated stroke and 30-day unplanned readmissions with new TTS were assessed. The primary outcome was the occurrence of death during index admission for stroke as well as during readmission episode with TTS. Incidence, factors and prognosis associated with TTS-complicated stroke and 30-day unplanned readmissions with new TTS were assessed. RESULTS: Of 3 376 606 patients admitted with primary diagnosis of stroke, 6119 (0.18%) developed TTS secondary to stroke. Patients with TTS were more likely to be women (79% vs 50%, p