Epilepsy surgery outcomes and their determinants: a systematic review and individual patient data meta-analysis

Journal of Neurology Neurosurgery & Psychiatry 2026 Open access

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Authors: T. Avigdor, Alyssa Ho, Matthew Moye, W. Davalan, E. Minato, Sana Hannan, Tamzin Holden, Tasha Bouchet, Yingqi Laetitia Wang, K. Jaber, Mays Khweileh, Samantha Jan Kaplan
+3 more Vojtech Travnicek, David Carlson, B. Frauscher
DOI: 10.1136/jnnp-2025-337158
Cited by: 1
References: 52

Abstract

BACKGROUND: Despite advances in epilepsy surgery, seizure freedom is achieved in only ~50-70% of cases, highlighting the need to better understand factors driving surgical success. METHODS: A preregistered systematic review and individual patient data meta-analysis was conducted on studies reporting clinical outcomes in epilepsy surgery, based on a comprehensive literature search through August 2024. Data were extracted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Unique patient data from 385 studies were pooled, yielding 5588 patients with outcomes, localisation, demographics, pathology and other findings. Surgical success rates (% Engel 1/ILAE 1-2) were reported with 95% Wald CIs. Associations with patient- and disease-specific factors were assessed using chi-squared tests (p

Fields of Study & Subjects

Epilepsy research and treatment Glioma Diagnosis and Treatment Pharmacological Effects and Toxicity Studies

Publication details

Journal / source
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Volume
97
Issue
7
Pages
639–648
Publication date
8 April 2026
Language
EN