PO:13:334 Grip strength, dexterity, and activities of daily living are independent predictors of poor quality of life in people living with systemic lupus erythematosus

Objectives Patients with Systemic Lupus Erythematosus (SLE) often experience impaired health-related quality of life (HRQoL) influenced by disease burden and physical dysfunction. Our study aimed to investigate the relationship between upper limb function and HRQoL in patients with SLE.Methods A total of 240 patients with SLE fulfilling the 2012 SLICC classification criteria and 122 age- and sex-matched healthy controls were enrolled. Upper limb function was evaluated by grip and pinch strength measurements and the Purdue pegboard test for dexterity. Activities of daily living (ADLs) were assessed using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. HRQoL was measured using the Lupus Quality of Life (LupusQoL) instrument. Associations between upper limb function, ADLs, and LupusQoL domains were examined using univariate and multivariate linear regression models adjusted for demographic, clinical, and treatment variables.Results Patients with SLE exhibited significantly reduced grip and pinch strength and lower dexterity compared to healthy controls (all p