PO:13:340 Unveiling the gap: a multicenter study on factors driving patient-physician discrepancies in assessing disease activity in systemic lupus erythematosus

Objectives This study explores discrepancies between physicians’ and patients’ reported Lupus disease activity and aims to identify key influencing factors.Methods Data from patients monitored consecutively between March and July 2024 at two Lupus Clinics were collected. Disease activity was assessed using a 0–3 visual analog scale for both Patient and Physician Global Assessment (PGA, PhGA).Results The study included 280 adult SLE patients (92.5% women, 93% Caucasian). Median age at enrollment was 46 years (IQR 37–58), and at diagnosis 29 years (IQR 20–38.5); 29% had primary schooling, 41% high school, and 30% a university degree. Most patients were employed; 10% students, 11% unemployed, 17% retired. ACLE was observed in 50%, SCLE in 9%, and 22% had CCLE. Mucosal, tumid, or hypertrophic SLE occurred in 1%. Ulcers affected 29%, alopecia 24%, arthritis 55%, pleuritis 9%, pericarditis 16%. Renal involvement occurred in 37%, neurological 9%, hemolytic anemia 10%, leukopenia/lymphopenia 60%, thrombocytopenia 22%. Concomitant conditions included antiphospholipid syndrome (10%), fibromyalgia (11%), and depression (14%).The last median SLEDAI was 2 (IQR 0–2), SLEDAS 0.37 (IQR 0.37–1.5). Steroids were used by 45%, DMARDs 94%, biologics 22%, and antidepressants/anxiolytics 32%. Median SDI was 0. Median PGA and PhGA scores were 0.58 and 0. Scores differed by > 0.5 in 52% of cases, with PGA generally higher (PhGA exceeded PGA in only 8). Strong concordance was observed (p