PO:13:348 Age-related patterns of organ damage impact on health-related quality of life in systemic lupus erythematosus

Objectives To characterise the age-related impact of organ damage patterns on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE) and to identify specific damage patterns affecting physical and mental health outcomes across different age groups.Methods In this cross-sectional study, 1,149 patients with SLE from the Asia Pacific Lupus Collaboration (APLC) cohort were stratified by age. HRQoL was assessed using the Short Form-36 (SF-36) questionnaire. Clinical characteristics and organ damage (SLICC Damage Index) were evaluated. Multiple linear regression analyses identified factors associated with the Physical (PCS) and Mental Component Summary (MCS) scores.Results Significant age-related differences were observed in physical HRQoL, with the age more than 50 years group showing lower PCS scores (median 52.6) than the