Sex differences in risk factor control and medication adherence post-ACS: insights from the TEXTMEDS randomised clinical trial

Open Heart 2026 Open access

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Authors: Shiva Raj Mishra, Simone L. Marschner, Haeri Min, Shehane Mahendran, A. Thiagalingam, Rohan S. Poulter, Julie Redfern, David B. Brieger, Peter Lindsay Thompson, Graham S. Hillis, Nicholas John Collins, Pratap Shetty
+8 more Michele McGrady, Christian Hamilton-Craig, Nadarajah Kangaharan, John Christopher Atherton, Andrew Maiorana, Harry Klimis, C. Juergens, Clara Kayei Chow
DOI: 10.1136/openhrt-2025-003856
Cited by: 1
References: 32

Abstract

INTRODUCTION: Poor adherence to risk factor control and life-saving medications is a key factor affecting long-term patient prognosis. Evidence indicates that sex plays a significant role in the uptake of both pharmacological and non-pharmacological interventions, ultimately influencing long-term outcomes. This study aimed to quantify sex differences in risk factor management and medication adherence following acute coronary syndrome (ACS). METHODS: This is a secondary analysis of the TEXTMEDS randomised clinical trial - a single-blind, multicentre randomised controlled trial of patients post-ACS. We compared sex differences in achieving clinical and lifestyle targets for secondary prevention, namely blood pressure control (

Fields of Study & Subjects

Medication Adherence and Compliance Cardiac Health and Mental Health Lipoproteins and Cardiovascular Health

Publication details

Journal / source
Open Heart
Publisher
BMJ
Volume
13
Issue
1
Pages
e003856–e003856
Publication date
1 January 2026
Language
EN