Diastolic dysfunction is equally common in pre-diabetes and diabetes and associated with concomitant cardiometabolic risk factors

Open Heart 2026 Open access

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Authors: David Kylhammar, Lina Hult, Peter Blomstrand, Hannes Holm Isholth, Amra Jujić, Martin Magnusson, Carl Johan Östgren, Jan Engvall, Kristofer Hedman
DOI: 10.1136/openhrt-2026-004052
Cited by: 1
References: 40

Abstract

AIMS: To investigate the prevalence of diastolic dysfunction and associated risk factors in pre-diabetes and diabetes in the general population. METHODS: Diastolic function was assessed by transthoracic echocardiography in a cross-sectional sample of 3840 men and women aged 50-64 years from the Swedish CArdioPulmonary bioImage Study. Anthropometry, medical history, blood pressure, biochemistry and coronary atherosclerosis assessed by CT were recorded. Population-specific reference ranges were applied. Diastolic function was compared across glycaemic groups and analysed in relation to risk factors. RESULTS: Normoglycaemia was present in 82%, pre-diabetes in 12% and diabetes in 6%. Diastolic function was impaired (p

Fields of Study & Subjects

Cardiovascular Function and Risk Factors Diabetes Cardiovascular Risks and Lipoproteins Cardiovascular Disease and Adiposity

Publication details

Journal / source
Open Heart
Publisher
BMJ
Volume
13
Issue
1
Pages
e004052–e004052
Publication date
1 January 2026
Language
EN