Analysis of perioperative methadone use in patients undergoing orthopedic procedures in the USA: a research report

Regional Anesthesia & Pain Medicine 2026

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Authors: Lisa Reisinger, Jashvant Poeran, Alex Illescas, Periklis Giannakis, Crispiana Cozowicz, Juliet Rowe, Junying Wang, Jiabin Liu, Ellen M. Soffin, Stavros G. Memtsoudis
DOI: 10.1136/rapm-2025-106880
Cited by: 0
References: 4

Abstract

Perioperative methadone, a long-acting opioid, may provide durable analgesia and reduce opioid requirements in high-pain orthopedic surgery (spinal fusion, total hip/knee arthroplasty, THA/TKA), yet use remains uncommon and highly variable across US hospitals.[1][1] We examined patterns of

Fields of Study & Subjects

Anesthesia and Pain Management Pain Management and Opioid Use Opioid Use Disorder Treatment

Publication details

Journal / source
Regional Anesthesia & Pain Medicine
Pages
rapm–2025
Publication date
25 February 2026
Language
EN